beta-Amyloid (1-40)
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beta-Amyloid (1-40)

633,20 zł
Brutto

0,5mg

Ilość
Czas dostawy 2 tygodnie

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Full Nameβ-Amyloid (1-40)
Alias
amyloid peptide; amyloid beta protein; beta amyloid plaques
Documents
β-Amyloid (1-40)Document-MSDS: 6021_20080924024159.PDF (PDF)
β-Amyloid (1-40)Document-HPLC: P17661405_RP10004_HPLC.pdf (pdf)
β-Amyloid (1-40)Document-MS: P17661405_RP10004_MS.pdf (pdf)
β-Amyloid (1-40)TECHNICAL MANUAL: Guidelines_for_Dissolving_Peptides.pdf (pdf)
β-Amyloid (1-40)Document-HPLC: P17661405_RP10004_HPLC.pdf (pdf)
β-Amyloid (1-40)Document-MS: P17661405_RP10004_MS.pdf (pdf)
Sequence
(one-letter code)
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence
(three-letter code)
{ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP} {VAL}{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}{GLY}{GLY}{VAL}{VAL}
Description
Beta-amyloid peptide (beta-APP) is a 40-residue peptide implicated in the pathogenesis of Alzheimer’s disease (AD) and aged Down's Syndrome, which is promoted by the acquisition of an additional copy of chromosome 21. The peptide is a proteolytic product of the much larger amyloid precursor protein (APP) encoded by a gene on chromosome 21. The peptide comprises a large extracellular N-terminal domain and a short hydrophobic membrane-spanning domain, followed by a short C-terminal region. Beta-APP both precedes and forms part of the transmembrane region.
Solubility
Insoluble in water, may be dissolved in any buffer of pH >9.
MW
4329.820
Formula
C194H295N53O58S1
Purity
> 95%
Storage
Store at -20°C
Notes
In culture, beta-amyloid peptide is neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons at higher concentrations. In differentiated neurons, it causes dendritic and axonal retraction followed by neuronal death.
Document-COA
GS1987